苏州桑拿

2014 Elite Eight Filming Announcement

first_imgTouch Football Australia (TFA) is pleased to announce that it has secured the services of RJ Media to professionally film and produce the 2014 Elite Eight series. Both the Men’s and Women’s Elite Eight finals will be professionally filmed on finals day of the 2014 X-Blades National Touch League, to be broadcast on Foxtel through April and May.  This has been achieved through the ongoing support of the TFA Board of Management and their vision for the elite game into the future as well as the overall benefits associated with the promotion of the sport across Australia.  TFA has a strong track record of working with RJ Media through Richard Scotts on projects including the 2011 and 2013 Elite Eight series as well as the 2012 Trans Tasman and State of Origin series’. To check out some of their work from the 2013 Elite Eight series, please click on the links below:2013 Elite Eight Men’s Finalhttp://www.youtube.com/watch?v=sJdH8lmIvrg2013 Elite Eight Women’s Finalhttp://www.youtube.com/watch?v=xTrnHxvVueIRelated LinksElite Eight Filminglast_img read more

22 days agoEverton U23 coach Unsworth: EFL Trophy good for development

first_imgEverton U23 coach Unsworth: EFL Trophy good for developmentby Paul Vegas22 days agoSend to a friendShare the loveEverton U23 coach David Unsworth was delighted with their EFL Trophy win over Burton Albion.Unsworth admits he’s a supporter for the competition and the potential introduction of B teams.Asked if the competition has worked for Everton, Unsworth told the Liverpool Echo: “Yeah, I think it has. It’s a competition we’ve been delighted to be in. For the first couple of years, there was almost a novelty for the players to play against first-team players.“You know me and you know I’m a big advocate of what happens everywhere around Europe with B-teams and for the purpose of developing young players quicker, it is brilliant the way they work throughout the leagues in Europe.”When we’ve had a sniff of playing first-team opponents, I’ve been all over it. Even in pre-season, it is something I feel very passionately about.“You’ve seen tonight, a very, very good mid-table League One club with an experienced manager, we’ve been the better team and won quite comfortably.”People slag off under-23s football, the Premier League do the best they can and it’s a league that has improved year after year and it’s not as bad as people make it out to be. You’ve seen that tonight.”Technically, we’ve looked the better team, we handled the ball brilliantly and the way we work proves it’s right, in terms of being like a first-team and working a lot on physicality and speed and tempo and limited touches because tonight we were just awesome.” About the authorPaul VegasShare the loveHave your saylast_img read more

4 days agoLys Mousset overjoyed to score Sheffield Utd winner against Arsenal

first_imgLys Mousset overjoyed to score Sheffield Utd winner against Arsenalby Freddie Taylor4 days agoSend to a friendShare the loveLys Mousset was delighted to score for Sheffield United in Monday’s 1-0 victory over Arsenal.The summer signing from Bournemouth endeared himself to the Blades faithful after his 30th minute strike sealed a memorable victory at Bramall Lane.He told Sky Sports: “It was a good feeling and it was good to be back in the team.”I wanted to say thank you to the manager for bringing me to Sheffield United and he told me just to play my football and try to score.” About the authorFreddie TaylorShare the loveHave your saylast_img

Report: ESPN To Buy Second Half Of Big Ten’s Media Rights For $190 Million Per Year

first_imgBig Ten logo.Twitter/@bigtenAfter FOX agreed to buy up half of the Big Ten’s available media rights for a reported $240 million per year, many speculated that a Big Ten/ESPN divorce could be on the horizon. FOX’s move does mean big changes for the conference, but ESPN will still have a major Big Ten presence. According to a report by Sports Business Daily, ESPN is set to buy the other half of the Big Ten’s package for $190 million per year over the next six years.ESPN will buy the second half of the Big Ten’s media rights package, ending months of speculation that the two were about to sever their 50-year relationship.ESPN will pay an average of $190 million per year over six years for essentially half the conference’s media rights package, according to several sources close to the talks. Two months ago, Fox Sports agreed to take the other half of the package for an average of $240 million per year. CBS Sports also has told the conference that it will renew its basketball-only package for $10 million per year.FOX will air the Big Ten Championship Game, and gets first choice for games, meaning that college football fans will be flipping to the network, and not ESPN, to watch Michigan vs. Ohio State in the future.FOX gets a game selection advantage over ESPN in that reported deal. So Michigan-Ohio State is probably moving to FOX for a while.— Nick Baumgardner (@nickbaumgardner) June 20, 2016With the combination of FOX and ESPN’s deals, the Big Ten is set to pull in $2.64 billion for its media package. On the field, you can have a very healthy debate over which conference reigns supreme, but in the bank accounts, it is hard to argue against what the Big Ten has pulled off this off-season.[Sports Business Daily]MORE FROM COLLEGE SPUN:The 10 Most Aggressive Fan Bases In CFBIn Photos: Golfer Paige SpiranacESPN Makes Decision On Dick Vitalelast_img read more

Conservative leader Stephen Harper clinches majority

first_imgAPTN National NewsConservative leader Stephen Harper seized his coveted majority Monday night after a tumultuous election campaign that propelled the NDP into previously uncharted popularity and left the once-powerful Liberal party in tatters.Harper’s Conservative party finally managed a breakthrough that seemed increasingly elusive despite failing to substantially increase their popular vote.The Tories gained seats in Ontario and has benefited in part from the NDP’s historic results, turning Jack Layton into the party’s first leader to become Opposition Leader in its history.The Liberal party was left in a decimated third place, hitting a historic low.The battled for second place between the surging NDP and the collapsing Liberals appears to have allowed Conservative candidates to come up the middle. It mirrors what former Prime Minister Jean Chretien managed in the vote split between the Progressive Conservatives and the Reform Party.The Liberals were not the only party to suffer from a crippling blow.The Bloc Quebecois faced major losses in Quebec, a province it once dominated federally, at the hands of the NDP which triggered an orange wave sweeping up the majority of ridings.last_img read more

Conical nanocarbon structures could lead to flexible transparent field emission displays

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Toward ‘invisible electronics’ and transparent displays Copyright 2010 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. In their study, Pradip Ghosh of the Nagoya Institute of Technology and his coauthors have demonstrated how to fabricate CNCSs on a transparent, flexible substrate at room temperature. The resulting CNCS-based electron emitter could then be used as a field electron emission (FEE) source for transparent, flexible field emission displays (FEDs). FEDs are a new kind of flat panel display that have several advantages, such as high contrast and lower power consumption than liquid crystal displays (LCDs). However, making FEDs transparent is very difficult since field electron emission requires a very high electric field and operation voltage. In order to achieve this high voltage, researchers usually use surfaces with a rugged sharp tip structure since the electric field is enhanced around the tip regions, enabling the operation voltage to be dramatically reduced. For this reason, as coauthor Masaki Tanemura from the Nagoya Institute of Technology explained, rugged surface structure is usually necessary for practical field electron emission sources, but so far ruggedness has not allowed for transparency.“Imagine sand-blasted glasses,” Tanemura told PhysOrg.com. “Glasses are transparent, but sand-blasted glasses are not due to the light scattering by the rugged surface structure. Similar to this example, transparency has not been possible for FEE sources.”By fabricating CNCSs that are smaller than the wavelength of visible light, the researchers found that they could overcome this challenge to produce fully transparent and flexible field electron emitters.“CNCSs have given transparency and flexibility to FEE sources for the first time,” Tanemura said. “To get CNCS-based transparent materials, it is highly desirable to control the diameter and length of the CNCSs. We have successfully controlled the diameter and length of the CNCSs below the wavelength of visible light at room temperature using an ion irradiation method. A careful scanning electron microscopy (SEM) inspection revealed that the diameter and length of most of the CNCSs were lower than the wavelength of the visible light. Thus this unique structure of the CNCSs was very useful to fabricate a CNCS-based transparent and flexible field electron emitter.” More information: Pradip Ghosh, M. Zamri Yusop, Syunsaku Satoh, Munisamy Subramanian, Akari Hayashi, Yasuhiko Hayashi, and Masaki Tanemura. “Transparent and Flexible Field Electron Emitters Based on the Conical Nanocarbon Structures.” J. Am. Chem. Soc. Doi:10.1021/ja909346e Explore furthercenter_img (PhysOrg.com) — During the past several years, researchers have used carbon nanotubes and nanofibers to fabricate a variety of transparent, flexible devices, such as OLEDs, transistors, and solar cells. But the development of transparent and flexible field electron emitters made of these nanomaterials still remains a challenge. In a new study, a team of researchers from Japan and Malaysia has shown that the key to the challenge may lie in the unique geometry of conical nanocarbon structures (CNCSs). In their experiments, the scientists bombarded a nafion substrate with argon ions for 30 seconds at room temperature. The irradiation produced uniformly distributed CNCSs over the entire nafion surface. The scientists measured that individual CNCSs had a base diameter of about 200 nanometers and a length/height of a few hundred nanometers, which is smaller than the wavelength of visible light. Overall, the material’s emission characteristics (its turn-on and threshold fields) were comparable to previous opaque electron emitters.As the researchers explain, the new method of using CNCSs for constructing transparent and flexible field electron emitters has several advantages. The method is simple in that it can be performed at room temperature, doesn’t require a catalyst, and doesn’t risk damaging the substrate. The scientists attribute these advantages to the unique conical geometry of the CNCSs. As a next step, the scientists plan to fabricate a transparent, flexible phosphor material, which is necessary for observing visible light emission and for the future construction of complete FEDs. The researchers predict that the technique could lead to transparent, flexible FEDs that are lightweight and inexpensive.“FED is a kind of flat panel display,” Tanemura explained. “Compared with other types of flat panel displays such as LCDs and electroluminescence displays, FED is advantageous in its brightness and size (a huge size is possible).” He added that transparent, flexible FEDs have great potential for applications including so-called head-up displays and highly intelligent information displays used in the coming ubiquitous world, when computers become thoroughly integrated into our everyday activities. “For example, head-up displays will be used on a curved front glass of vehicles (airplanes, trains, cars, and so on), full-face helmets, spectacles, and so on,” he said. “Usually it is transparent, but various kinds of information, such as maps, customer information, alarms, and security, will be displayed on demand. In the ubiquitous world, displays should be foldable (rollable) and light for mobility. You can enjoy TV, movies, games, communication, and obtain various kinds of information using an unfolded wide screen. Transparent and flexible FEDs make it realistic!” Citation: Conical nanocarbon structures could lead to flexible, transparent field emission displays (2010, March 25) retrieved 18 August 2019 from https://phys.org/news/2010-03-conical-nanocarbon-flexible-transparent-field.html This SEM image shows conical nanocarbon structures (CNCSs) fabricated on a transparent and flexible nafion substrate. Because the CNCSs are smaller than the wavelength of visible light, they have given transparency and flexibility to field electron emission sources for the first time. Image copyright: Pradip Ghosh, et al. ©2010 ACS.last_img read more

0 Comments  

first_img 0 Comments   Share   The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo 4. Darnell Dockett, DL, Florida State, 2004, 3rd round (64th overall)The franchise may not have loved Dockett’s infamous antics off the field (and sometimes on the field), but there was no doubting Dockett’s motor and heart when he was healthy. In 10 NFL seasons, Dockett made three Pro Bowls and in 2007, he posted a career-high nine sacks. His powerful backstory made it hard not to root for Dockett in spite of his myriad missteps. 2. Adrian Wilson, SS, North Carolina State, 2001, 3rd round (64th)Wilson is still one of the franchise’s all-time icons after a 12-year career in the Valley. He made the Pro Bowl five times, he has the most sacks by a defensive back in a single season in NFL history (8, 2005), he is one of just six players in NFL history with 25 interceptions and 25 sacks and he set the tone for the Cardinals defense with his hard-hitting, no excuses approach. He was welcomed into the Cardinals Ring of Honor in 2015. Derrick Hall satisfied with D-backs’ buying and selling 5. David Johnson, RB, Northern Iowa, 2015, 3rd round (86th overall)Some believe Johnson is already the best all-around running back in the NFL, and the stats bear that out. Johnson’s 2,118 combined rushing and receiving yards were the most in the NFL last season, but the third-year player admitted this week that he has much work to do in pass protection. “I had so many errors that hurt our team,” Johnson said. “I definitely missed a lot of blocks and I missed a lot of linebackers and hurt Carson, got him sacked or made him rush the throw.” There is still upside in Johnson’s game.Honorable mentionTyrann Mathieu, LSU, 2013, 3rd round (69th overall)Pat Tillman, SS, ASU, 1998, 7th round (226nd overall)Steve Breaston, WR, Michigan, 2007, 5th round (142nd overall)Antonio Smith, DE, Oklahoma State, 2004, 5th round (135th overall)Renaldo Hill, CB, Michigan State 2001, 7th round (202nd overall) TEMPE, Ariz. — Cardinals GM Steve Keim and his scouting staff have developed a reputation for finding quality players in the later rounds of the NFL Draft, particularly the third round. It’s a necessity when building a successful franchise, and NFL history is littered with guys who made their bosses look like geniuses.Hall of Famer Deacon Jones was a 14th-round pick. Quarterback Roger Staubach went in the 10th-round. New England QB Tom Brady was a sixth-round pick. QB Joe Montana went in the third round. Cardinals Hall of Fame safety Larry Wilson went in the seventh round, while tight end Jackie Smith, another Hall of Famer, was a 10th-round pick. Follow Craig Morgan on Twitter Former Cardinals kicker Phil Dawson retires 3. Aeneas Williams, CB, Southern, 1991, 3rd round (54th overall)With a name from Greek mythology, Williams was destined for greatness. He made eight Pro Bowl appearances, grabbed 55 interceptions in his 14-year career and earned a reputation as one of the league’s best lockdown corners. He also made a name for himself with several signature plays. In 1998, Williams helped the Cardinals win their first playoff game since 1947 by intercepting two passes from QB Troy Aikman in a 20-7 win over the Cowboys, and he added another pick in a 41-21 loss in the divisional round. In 2000, he tied an NFL record by returning a fumble 104 yards for a touchdown in a game against the Redskins and, in Week 3 of the 1999 season, he delivered the hit that ultimately ended 49ers QB Steve Young’s career. Here, in our opinion, are the five best draft-day steals (no particular order) in Arizona/Phoenix Cardinals history (Chicago and St. Louis years excluded). For this list, we have eliminated first and second-round picks because teams typically expect a major impact from those players. That discounts three-time Pro Bowl receiver Anquan Boldin, a second-round pick (54th overall).Whittling the list to five was difficult, especially with a couple recent third-round picks throwing their names in the hat. Ultimately, we left safety Tyrann Mathieu out of the top five due to recurring concerns over his health, but he could displace one of our top five with a return to form.1. Larry Centers, FB, Stephen F. Austin, 1990, 5th round (115th overall)Centers played 14 NFL seasons, nine of them with the Cardinals. He was a three-time Pro Bowl selection. In 1995, Centers had one of the best seasons ever logged by a fullback, catching 101 passes for 962 yards. The 101 receptions were an NFL record for the most in a single season by a back until Chicago’s Matt Forte broke the mark with 102 in 2014. Centers followed that season with 99 catches for 766 yards and seven touchdowns, while also gaining a career-high 425 yards with two rushing touchdowns in 1996. Centers finally made the playoffs in his final year in Arizona (1998) and then won a Super Bowl with New England in 2003. Grace expects Greinke trade to have emotional impact Top Stories last_img read more

Bellinos spring cleaning proposal receives overwhelming House support

first_img Categories: Bellino News 24May Bellino’s ‘spring cleaning’ proposal receives overwhelming House support The Michigan House Wednesday voted overwhelmingly to approve a plan sponsored by state Rep. Joe Bellino removing an unnecessary law from the books.Bellino’s plan removes a duplicative reporting requirement within the Office of Community Corrections. Submitted reports outlining funding requests were once received by the state, but that information is now redundant since it is submitted to the Legislature each year within the Michigan Department of Corrections budget.Bellino’s proposal is part of a bill package that he and his House colleagues have been working on to clean up state government and have it run more efficiently for the people of Michigan.“More often than not, regulations in state law are duplicative to others,” said Bellino of Monroe. “My plan, as well as plans sponsored by my colleagues in the Michigan House aim to get rid of unnecessary regulations to keep our government clean and limited.”House Bill 5997 now moves to the Senate for further consideration.last_img read more

Rep OMalley on State of the State Prioritize skilled trades and Michigan

first_img State Rep. Jack O’Malley, of Lake Ann, issued the following statement after the governor’s State of the State address:“Michigan’s economic comeback depended on smart investments and I’m dedicated to working with my House colleagues, listening to the people we represent and acting in their best interests.“Record investments in K-12 schools and a renewed, modern focus on hands-on skilled trades gives students important training for high-quality careers. We must continue to invest in improving our schools to give our kids the best possible opportunities.“We are also investing more than ever into our roads that drive our economy. Michigan needs more than a vague plan and a catchphrase. The people we represent want to see their tax dollars spent wisely on priorities that matter. We need to figure out how to get more out of every dollar we use, rather than increase the bill for taxpayers.”### 13Feb Rep. O’Malley on State of the State: Prioritize skilled trades and Michigan roads Categories: News,O’Malley Newslast_img read more

Satellite operator SESs Brazilian subsidiary SES

first_imgSatellite operator SES’s Brazilian subsidiary SES DTH do Brasil has secured frequency rights at two new orbital positions – 48° West and 64° West – following an auction organised by Brazilian telecoms regulator Anatel. SES now has four years to make capacity available at 48° West and six years to make capacity available at 64°. At the 48° West position, SES will focus on multiple uses of fixed satellite services and will operate in C-, Ku- and Ka-bands.The 64° West orbital position will be exclusively for direct-to-home use. The exploitation rights are valid for 15 years, renewable once for the same period. SES invested a total of BRL59.8 million (€19.7 million) in securing the new slots.last_img

Breweries are quite creative these days when it co

first_imgBreweries are quite creative these days when it comes to saving energy. Double Mountain Brewery in Oregon uses refillable beer bottles, Five & 20 Spirits and Brewing turns its waste grain and water into compost for aquaculture, and Sierra Nevada Brewing Company recovers carbon dioxide from the fermentation cycle.Investment in energy-efficient technologies can be costly, but according to a study published last week in PLOS ONE, these investments may be worthwhile.A majority of the 1,000 U.S. beer drinkers surveyed say they are willing to pay more for sustainably-produced beer, and on average, they would pay around $1.30 more per six-pack.”One dollar and 30 cents is not a small amount if you consider the average price of a six-pack,” says Sanya Carley, an associate professor at Indiana University Bloomington’s School of Public and Environmental Affairs, and the lead author of the survey.According to data from IRI Worldwide, a Chicago-based market research firm, the average price of a six-pack of beer is $5.96. For craft beer specifically, an average six-pack costs $9.36.The survey reached respondents through Amazon’s Mechanical Turk, a crowdsourcing survey tool. Participants were asking if they were willing to pay more for beer produced at breweries that invest in equipment to conserve water or energy or use solar panels to limit greenhouse gas emissions.The findings of the willingness-to-pay survey underscores the opportunity to reduce greenhouse gases in the highly energy-intensive brewing industry, she says.It’s so energy intensive that it takes three and a half to six gallons of water to produce one gallon of beer, according to the California Craft Brewers Association.Fifty-nine percent of respondents to the survey said they would pay more for beer that invests in sustainable practices.Bart Watson, the chief economist of The Brewers Association, says these findings are pretty much what he would expect based on recent trends in the beer market.”An increased number of people are willing to pay more to companies that share their values,” Watson says.Jason Perkins, a brewmaster at Allagash Brewing Company, a craft beer brewery in Portland, Maine, says this research makes him “ecstatic.””It’s important for us to be making beer responsibly,” he says, but it’s also important that consumers are willing to pay more for a sustainable product.Allagash, which has put a number of sustainability practices in place including waste diversion, composting, cork recycling, and using locally-grown grain, put in a solar array in 2016 after contemplating the investment for awhile.The company knew the solar panels would be a big upfront expense, but decided to take the leap.”It was really a decision based on a matter of principal,” Perkins says. He also says it’s a little hard to quantify what all of Allagash’s sustainability practices mean to the company. The solar panels, for example, allow the company to displace thousands of pounds of CO2 that would have been produced through traditional energy generation. Also, Allagash employees are just proud to be doing good things for the environment, he says.But its not just the growing craft beer industry that can potentially benefit financially from marketing sustainability. The research from the recent study shows that consumers of American lagers like Budweiser and Pabst Blue Ribbon were no different than other beer drinkers in their willingness to pay for sustainable beer. This finding was unexpected and encouraging, says Carley.”It’s refreshing in a way because sustainable practices don’t have to be limited to just craft beer companies,” Carley says.By the way, big beer companies are already taking steps towards sustainability. For example, MillerCoors has already significantly reduced its water usage.But according to Ernest Baskin, an assistant professor of consumer behavior at Saint Joseph’s University, it’s important to note that in the study, the consumers who were more willing to pay for sustainability premiums already said they tended to pay more money for beer than the consumers that were unwilling to pay more for sustainable beer. Thus, for beer companies that market themselves as “for the common man,” he says, sustainability measures might not be an added benefit. They might, in fact, price these companies out of their major consumers, Baskin says.Watson points out, though, that large beer companies have broad portfolios (Anheusuer-Busch sells a lot more than just Bud Light), and these findings on consumers’ willingness-to-pay for sustainability might factor into the business models for their specialty products.The research, Watson says, “might push some more breweries that are thinking about this to make sustainable investments.”Rachel D. Cohen is an intern on NPR’s Science Desk. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Nab an Adidas 3DPrinted Sneaker This Fall

first_img Free Webinar | July 31: Secrets to Running a Successful Family Business Image credit: Adidas via PC Mag Learn how to successfully navigate family business dynamics and build businesses that excel. Tom Brant –shares The company’s first production shoe with a 3D-printed design uses a technology that was originally conceived in the 1980s for rear-projection TVs. Nab an Adidas 3D-Printed Sneaker This Fall This story originally appeared on PCMag 3D Printerscenter_img 2 min read News reporter Add to Queue Next Article April 10, 2017 After years of experimenting with 3D-printed footwear, Adidas on Friday announced that its first mass-produced 3D-printed shoe, the Futurecraft 4D, will go on sale this fall.The shoe’s sole is shaped using digital light projection, a technology you might be familiar with if you shopped for a rear-projection TV 20 years ago. Despite rear-projection’s demise, the technique is still alive in the 3D printing industry: it projects patterned light onto a liquid photopolymer resin, shaping and hardening it into layers. To make the Futurecraft 4D’s sole, Adidas partnered with the Silicon Valley startup Carbon, which says that its digital light synthesis technique is more efficient than ordinary 3D printing, and thus better-suited to making large quantities of durable goods. According to Texas Instruments, which originally developed the digital light processing concept in the 1980s, it’s now used to quickly print everything from prototypes, jewelry casting, custom medical implants and complex automotive and aerospace components.In Adidas’s case, digital light synthesis results in a sole that works just as well as one made in an injection mold and has similar costs and production times. The company plans to sell 5,000 of the Futurecraft 4D this fall, and an additional 10,000 next year. Pricing hasn’t been announced yet; Reuters reports that the shoes will sell at an “unspecified premium price,” but Adidas plans to lower the cost as the technology develops.Despite the benefits that 3D printing promises to bring to shoe design and manufacturing, it has been a gradual development process for Adidas and its competitors, at least compared to the consumer tech lifecycle. In 2013, New Balance became the first athletic brand to have a track athlete — middle distance runner Jack Bolas — compete in 3D-printed spike plates. But it wasn’t until three years later that the company managed to sell a 3D-printed shoe to the public in the form of a limited-edition $400 sneaker.Adidas, meanwhile, unveiled the Futurecraft 4D’s predecessor as a concept shoe in 2015. It used thermoplastic polyurethane instead of resin shaped by digital light projection. Register Now »last_img read more

Ready for Microsofts Vista

first_imgTechnology Next Article Magazine Contributor –shares Microsoft’s Vista promises to be the next big thing in Windows computing–literally. Will your PC be PC enough for Vista when it drops a few weeks from now? If not, AMD and Intel might be able to brighten your holidays. They’ve begun shipping a new generation of more powerful dual-core processors, forcing bone-deep price cuts on “old” dual-cores and Pentium-class chips.Just about any new computer will run Vista Starter or Basic now. Less clear is how much PC you’ll need to make the most of the new Windows. It depends on how graphical you want to be. Will you run the 3-D Aero “glass” interface? Make VoIP calls? Create a video blog? Watch TV on your PC? The extra vroom needed might still fit your budget.The long run-up to Vista has been hard on people who sell PCs–but great for people who buy them. Sales have languished for most of the year with a corresponding buildup in chip inventories and softening in prices. Intel and AMD finally began slashing 40 percent or more off first-generation dual-core prices last quarter to make room for a new dual-core generation.Competition being what it is, most of those savings get passed on to PC buyers as a mix of lower prices and hardware improvements. As recent corporate earning releases show, PC sellers have been giving away margin until it hurts.But lucky for Microsoft, hardware companies are playing through the pain. It starts with Intel and AMD, who can’t seem to stop one-upping each other with ever-faster and cooler chips. Intel’s new Core 2 Duo family forces deep price cuts in first-generation Core Duos that haven’t even had time to lose that new-chip smell. And the long-running Pentium line? That’s over. AMD’s new AM2 platform has a less dramatic debut–primarily, bringing DDR2 and other memory innovations to the midrange Athlon 64 X2 and top-of-the-line Athlon 64 FX-62. Register Now » Add to Queue This story appears in the November 2006 issue of Entrepreneur. Subscribe » November 1, 2006center_img Ready for Microsoft’s Vista? Mike Hogan 4 min read Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. New chips, lower prices–maybe you can afford that Vista PC after all. State of ReadinessAt first glance, Vista’s hardware requirements don’t sound that onerous–an 800MHz CPU for basic versions, a 1GHz engine for the Aero interface. Vendors haven’t sold PCs that slow in years, although millions are still out there, doing their jobs faithfully every day. But it’s not enough just to run Windows. You also need enough PC for bigger, better software versions–starting with Microsoft Office.It’s odd that clock speed is emphasized, because memory is much more important. Figure on a full gigabyte of system memory to be “Vista Ready” for Aero–and better make that DDR2 memory. Also, choose a processor with as much cache memory behind as wide a front-side bus as you can afford. Get at least 1MB of L2 cache–2MB would be better–and 4MB would put snap in your apps. And pick a graphics adapter with at least 128MB dedicated video memory.The impact can be seen in recent performance tests where Intel’s second-generation Core 2 Duo processor did 40 percent more work running at 2.66GHz than a first-generation dual core did at 3.6GHz. Either of the twin engines in Core 2 Duo can tap the full 4MB of cache they share as needed, but each first-generation dual-core engine is limited to 2MB. Core 2 Duo’s engines also benefit from a one-third wider front-side bus to memory and other efficiencies in Intel’s new Core microarchitecture.But these improvements sure complicate shopping. You can depend on vendors to label which Windows XP systems they’re selling today are Vista Ready or Vista Capable. But to get the most for your money, you may need to weigh two or three different options in each of the memory categories.PC vendors have been blowing out last-generation models and filling their price points with new, more powerful configurations up and down the product line. For example, at this writing, Dell’s cheapest Core 2 Duo model was packed with 1GB DDR2, 4MB L2, a 1066MHz FSB and nVidia Geforce video with 256MB. Price: $1,600–including a 20-inch flat panel!There’s just a lot more PC under the average price tag now. And Vista? Not a problem–at least, not for new PCs.Mike Hogan is Entrepreneur’s technology editor. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goalslast_img read more

The Webs Best Mapping Sites

first_imgTechnology 15+ min read Steve Bass Next Article –shares September 6, 2007 Add to Queue Sure, getting from point A to point B is still a big reason for using one of the Internet’s many mapping sites, but these days there’s a lot more to Web maps than just directions. I looked at the five biggest names in online maps–Ask City, Google Maps, MapQuest, Microsoft Live Search Maps, and Yahoo Maps–and found that annotation and other tools gave Microsoft Live and Ask City a slight edge over Yahoo Maps, and a substantial advantage over Google Maps and MapQuest. I also tried a slew of location-based services . And don’t miss our guide to the top map mashups .Chart a Course for the Best Mapping SitesTraffic reports, 3D views, and the ability to add notes are among the new features that help take the bumps out of your travels. Click on the text link or the icon below to see our ranked chart of the five mapping services we tested.The Best Mapping Sites (chart)Ask CityThere are enough drawing tools on this site to keep you busy for hours gussying up your maps. You can add text notes or draw segmented lines, squares, circles, and polygons, in any of ten colors. It’s easy to undo individual additions or to clear the map completely.One great Ask City feature is that it lets you add a stickpin to any location and fill it with an image and notes. You can save snapshots of up to ten maps (including all your gaudy annotations). Click Permalink to save a link to the map, or send others the link via e-mail.Options in the Search panel enable you to look for a local business, movie theater, concert, or other event, or generate maps and directions. In late July I searched for “Harry Potter” and “Pasadena,” and Ask City’s middle Results panel listed ten local theaters playing the movie, each pinned onto a map in the right-hand panel. The three windows let you dynamically view changes on custom maps. In the Results panel, for example, clicking the name of a business–say, a restaurant or hotel–usually brings up a Citysearch review.Once you search for a specific type of business (“manicures,” for example), Ask City supplies a list of businesses in the area, with the neighborhood highlighted on the map. Way cool.Another appealing Ask City feature: Click any of the written directions in your route to have that area appear on the map, along with a second, smaller inset map corresponding to the specific route section. You can add up to ten stops to the map at a time.If you’ll be walking, click the Walking tab on a plotted route to see directions optimized for traveling by shank’s mare. I was even able to create and save a walking tour in Paris, in case I ever travel there again. Right-click your map to add the location, or snap to the closest address, and stick in a location pin.The service’s directions and map panels have minimize and maximize icons for resizing the contents; however, on conventional 4:3 monitors, you might need to scroll to the right to see them.Google Maps and MapQuestGoogle MapsWhen I think of mapping sites, I think Google. So it’s too bad that the service’s interface is so cluttered, especially compared with the clean interfaces of the other top mapping sites I visited.One of the best things about Google Maps is that it lets you dynamically change the route of a trip: Start a route with a mouse click, choose the start and end locations, and then just drag a section of the route and drop it elsewhere on the map. In a flash, the directions on the map change–as do the written directions. That’s a great feature for rerouting if you should discover a backup on your route (and you will, trust me) by clicking the Traffic button.Right-click the route to add more yellow pushpin stops, or add stops via the written directions in the Search Results panel; or you can drag and drop written instructions to rearrange the route.Google Maps also lets you create your own mashup by adding content from hundreds of sources. For instance, the My Maps feature can now display elevation contour lines or gas prices (the latter via the Gas Buddy plug-in).You can save up to 100 map locations, but doing so requires that you log in to a Google account (click Sign in to start creating one). To make your maps easier to retrieve, use Google’s My Maps tab. Another option is to create a link for sending maps via e-mail. However, the only data you can send to a cell phone is a business location.Unfortunately, Google Maps’ annotation tools are paltry compared with those of Ask City and Live Search Maps. Google does let you add placemarks and include .rtf, .html, and other files; you can draw segment lines and shapes, but you can’t draw circles, and you can’t embed text directly on the map.Even worse, I spent way more time figuring out the service’s controls than I did actually creating and annotating my maps. Google Maps simply isn’t as easy to use as Live Search Maps or Yahoo Maps. After much struggling, I discovered that the annotation tools were available only if I chose Create new map under the My Maps tab.I was also bewildered by the right-click options, which changed depending on the map view. For instance, a “clear map” button to start over was available in a business search, but not in the map’s own search feature.MapQuestIf you’re looking for an easy-to-use mapping service that’s not all fancy-shmancy, AOL’s MapQuest may be for you. The site focuses primarily on routing and directions, though you can zoom in on specific map locations. To get directions, enter an address or intersection as the starting location. Ditto for the destination. (Click the Maps icon if you just want to explore a map.) You can exclude seasonally closed roads.MapQuest’s step-by-step directions feature expandable maps highlighting each turn or other instruction; click Open or Close at the top of the map to expand the directions.Clicking the route’s starting point or endpoint brings up the helpful ‘Zoom to Street Level’ link; you have the option of switching to a hybrid satellite view, too.One nice MapQuest feature is the ability to reorder your route by dragging and dropping the written locations to a new spot on the list. It seems silly, though, that MapQuest doesn’t let you save a multistop route.To arrange for maps on the go, use the Send to Cell option, which dispatches a text link that you click on your mobile phone to open the map and directions in the phone’s browser.The flashing, twirling ads on MapQuest are annoying; they’ll eventually stop–until your pointer touches the ad.Microsoft Live Search Maps and Yahoo MapsMicrosoft Live Search MapsI didn’t think anything would get me off Google Maps, but after using Live Search Maps just once, I was hooked. It’s packed with features that make it more like a full-blown application than simply a mapping service. My favorite: the roll-up Scratch pad, which makes saving trips, routes, and maps a breeze (get to it by clicking CollectionsOpen). Of course, in order to save your Scratch pad, you first have to sign in with a free MSN or Hotmail account.You can use the Scratch pad to draw a path or trail, and a pop-up shows the distance in yards and in miles. The service lets you create a rectangle, square, or other straight-line area, with the color fill or border width of your choice. (One missing feature is the ability to add text directly onto the map.)Live Search Maps makes it easy to save annotations as a collection (to do this, click Properties, Save). You can share your map via e-mail, or pop it onto the Windows Clipboard for subsequent pasting into an application.Right-click to zoom to a street or regional level, or to add a pushpin with notes that include a URL and a link to an image. That same right-click lets you start planning a route by adding a ‘Drive from’ (or ‘Drive to’) pushpin, and then finishing the route in the written ‘Driving directions’ panel. (Or you can simply add both ‘Drive from’ and ‘Drive to’ pushpins on a map, and click Get directions.)Unlike Ask City, Live Search Maps doesn’t let you force the pushpin to connect to a specific address. But when you’re at a street-level view, you can spot and select the location you want (the Las Vegas Hilton, say), which is adequate for most routing needs.The service’s live traffic icons include one that identifies planned events, such as a trade show or baseball game. Two nice touches: The Navigation tool rolls out of the way; and as in Yahoo Maps, a handy minimap aids in navigation.Live Search Maps shows the typical road, aerial, and hybrid map views, but much more stunning are the Virtual Earth 3D views. Still, as with the 3D images on Google Maps, the novelty wears off surprisingly quickly: After about a dozen 3D views, I found myself using Live Search Maps just to perform straightforward mapping and routing.By the way, if you want to use Virtual Earth, you’ll need to download an ActiveX program–which, to my dismay, attempted to change my browser’s home page to Live Search. Microsoft’s mapping service also offers you a Location finder, which is a small application that tries to identify your exact current location based either on the Wi-Fi hotspot you’re using or on your IP address. But without Wi-Fi, the “Locate me” feature wasn’t able to find me when I tested it.Yahoo MapsThis mapping service is smart about creating a route, but it’s not perfect. For example, Yahoo Maps couldn’t find “Museum of Natural History, Los Angeles” when I entered it into the ‘Get a Map’ and ‘Get Driving Directions’ fields, yet it popped up immediately in the ‘Find a Business on the Map’ field. The service found New York’s Times Square in all three search spots immediately, and it located several street addresses. However, it drove me nuts that the site couldn’t find matches for a location I had previously searched for and saved.When you create a route and hover over any portion of the text directions, the route segment is highlighted on the map (although I would have preferred that it change color rather than simply acquiring a highlight). Clicking the chevron symbol on any written direction will cause its small map portion (which is also individually printable) to unfold.The service’s routing results were accurate, and I liked the nearly instantaneous real-time traffic icons; it was also nice to see road closures displayed. You can send the map and instructions via e-mail. Also, street addresses appear as links in Yahoo Mail messages, leading to Yahoo Maps.The mapping details on Yahoo Maps really shine. For instance, at the street level, little purple “P” icons signify parking structures. If you look carefully, you will see the details of freeway on- and off-ramps. And you may notice that some maps have color-coded neighborhoods (which, unfortunately, you can’t use as a search criterion).Yahoo Maps is loaded with tools that help you use the site more efficiently. For instance, as you hover over the tool that lets you zoom in and out of a map view, little markers for street, city, state, and country appear. If you’re browsing a map and want directions to a particular spot, right-click and choose Drive from here… or Drive to here…. Another nice touch: The minimap insert (which rolls up when not needed) is superimposed on the larger map and makes navigating much more pleasurable.There’s no 3D mapping, but Yahoo Maps provides enough texture on its satellite and hybrid maps to let you discern mountains and hills, and get a sense of other terrain. Yahoo Maps also figured out that not everyone is on a fast connection, so for dial-up users it offers another site that has almost all of the same features but isn’t as bandwidth-hungry.Mapping and Location Services for Your Cell PhoneYou’re out and about and need some quick information, or you simply want to find out where you are or whether your buddies are close by. Grab your cell phone and try one of these free and low-cost services.Tell Me All About ItCall Tellme (800/555-8355, or text 83556) and say “weather,” “sports,” “news,” “taxi,” “airlines,” or “driving directions.” You’ll see a map, directions, or search request results on your cell phone (you’ll need to download a small application first). The service works with AT&T and Sprint phones. Note: Tellme was acquired by Microsoft earlier this year.Keep Track of YourselfTrimble Outdoors has a trio of subscription-based tools that use your cell phone to show you exactly where you are and where you have been. In real time, its AllSport GPS records your walk, jog, or bike ride; you can see your route immediately on your cell’s screen and keep a record on the service’s site. It works with most Garmin and other popular GPS devices (plug-in required). If you’re into geocaching, where you try to find hidden treasures or do other tasks using a GPS, you’ll get a kick out of Trimble’s Geocache Navigator service. Trimble Outdoors also gives you a way to plan routes and trips with street, satellite, and topological maps. The cost for all three is $7 per month.Get a Jott JoltIf you have a reminder (or bright column idea) to send to yourself, or a message that you need to get to a friend or a bunch of buddies, use Jott . Call 877/568-8486 and record a voice message up to 30 seconds long that the service transcribes into text and sends as a text alert to the e-mail addresses or mobile phones of your choice. Jott even saves the messages for future reference. You can also import your Web mail address book.Don’t Dodge MeIf you want to locate your pals, or let them find you, sign up for the Dodgeball service, and use your cell phone to let them know where you are and to find out where they are. Available in over 22 cities, Dodgeball lets you broadcast your location by texting your street address or other information about your locale to 36343, along with a text message–and maybe a snapshot of you and Paris. In no time, you’ll be surrounded by friends, and maybe a hundred paparazzi.Find Out Where to GoNature calls, even in the big city. So when you’re running all around town, you may need to know where you can go on the go. MizPee has the answer, providing the location of clean, dependable lavatories. Use your phone’s browser to access the beta service, or (easier) text your city and state to 415/350-2290.Mapping MashupsMapping on its own is great, but a good mashup–data from two inherently different sources combined–is glorious. And often lots of fun. (See ” Eight Great, Simple Ways to Hack the Web ” for more on the technology.)Take a Geowalk WalkI spent an hour exploring the world with the widgets on Geowalk’s virtual desktop . Pop a location into the Geocoder field and click a pushpin on the map. You’ll see detailed information and location-related pictures as Geowalk mashes up Wikipedia info and geo-tagged Flickr photos. Tap the More button on the UNESCO World Heritage widget for a neat surprise.Read a Book, Sip Some CoffeeSilly as it sounds, some people need a regular caffeine-and-literature fix. Findbyclick locates a nearby Starbucks or chain bookstore in over 100 cities in the United States and Europe. Click a link, and you’ll get a location; sort the tags to find a spot with Wi-Fi.Did You Feel That?Everybody in California is waiting for it: The Big One. When you live in earthquake country, you know it’ll happen. That’s why I’m a fan of the U.S. Geological Survey’s mashup of Yahoo Maps and real-time, worldwide earthquake reports.Map Your New Craigslist Digs Craigslist.org is famous for finding the apartment that’s just perfect for you. But if you’re tired of the drudgery of scrolling through the classified-ad site’s endless lists, try MapsKrieg –its mashup helps do the job for you. Just choose a region, or enter a specific city and state, and browse around the pushpins to find the ideal location–like a fully furnished five-star flat in Tribeca for only $4400 a month. If you prefer searching by price (no kidding!), try Housing Maps instead.Taxi…TAXI!When you travel to Los Angeles, Boston, New York, Las Vegas, or some other big city, don’t get taken and pay too much for your ride around town. TaxiWiz gives you an estimate of the fare for trips in seven major cities, reducing the chances that you’ll be fleeced by unscrupulous taxicab drivers. For instance, a trip from L.A. International Airport to my office in Pasadena shouldn’t run more than $75. (Never mind, I’ll pick you up.) There’s also a mobile version of the service if you can’t get to a PC.Personalize Your Mashup MapUse Platial and consider yourself a neogeographer–someone who shares locations of personal significance with family, friends, or strangers. Two of my favorite Platial offerings: Jordi’s Mad Jaunt Across America and Baostar’s best spots in Orange County, California, for a Zen fix .Duck and CoverNo matter where you go, there’s something to worry about. The Global Incident Map does a tremendous job of letting you track terrorist attacks and other potential calamities. The mashup integrates data from newspapers, Web news reports, and other sources with Google Maps. Click an entry on the map for more info and a link to a detailed report on the incident.Look at Clouds From Both SidesHey, Bill, is it cloudy in Seattle? Don’t bother looking up–of course it is. Get a view of the clouds over any location worldwide at DaylightMap’s Clouds page . The satellite and hybrid views appear through the haze of cumulus (or are they nimbus?) clouds. The NASA images are are updated every 6 hours.Banks, Traffic, and MoreMost mashups come with one service. But MoreMap is the Grand Poobah of map mashups. The site supplies access to mapping mashes for banks, movie theaters, traffic conditions, radio stations, weather, earthquakes, and other categories. Find your way with the Directions modules; the site’s free registration lets you store your favorite places and access them from any Internet-connected PC.center_img Register Now » The Web’s Best Mapping Sites Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Brought to you by PCWorld At the top map services, driving directions are just the beginning. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goalslast_img read more

Canadian smokers support novel policies to reduce tobacco use

first_img Source:https://uwaterloo.ca/ Reviewed by James Ives, M.Psych. (Editor)Oct 12 2018Most Canadian smokers are in favor of novel policies to reduce tobacco use, according to a national survey by the International Tobacco Control Policy Evaluation Project (ITC) at the University of Waterloo.Responding to the Canadian government’s commitment to reduce tobacco use to less than five per cent of the population by 2035, the ITC study assessed baseline levels of support among Canadian smokers for potential endgame policies. The researchers found that most smokers in Canada support new and radical tobacco endgame strategies.”Canada has taken strong actions to reduce tobacco use over the last several decades. Anti-smoking policies such as graphic warning labels on cigarette packs, smoking bans, tobacco taxes, and bans on the display of tobacco products have driven smoking rates down to an all-time low,” said Geoffrey Fong, Principal Investigator of the ITC Project and a professor of psychology and public health and health systems at Waterloo. “However, the decrease has leveled off in recent years, and 16 per cent of Canada’s population (roughly five million people) continue to smoke — killing 45,000 smokers each year.”Related StoriesCo-use of cannabis and tobacco associated with worse functioning, problematic behaviorsStudy: Tobacco and alcohol usage are common in British reality television showsWorld No Tobacco Day 2019: Respiratory groups urge to strengthen WHO Framework Convention on Tobacco ControlThe survey of 3,215 smokers, conducted in 2016, found that 70 per cent support lowering nicotine levels in cigarettes to make them less addictive and raising the legal age for buying cigarettes to 21+ years. More than half (59%) of smokers support a ban on all marketing of tobacco products. Even the most radical policy proposed in the survey — a complete ban on the sale of cigarettes within 10 years, with smoking cessation support — is favored by 44 per cent of smokers.On May 31, 2018, the Canadian government released a new federal tobacco control strategy to achieve a tobacco endgame target of less than five per cent tobacco use by 2035 – or less than 1.8 million tobacco users. The study findings support the kind of new leading-edge policies needed to curb tobacco use in Canada and refutes typical tobacco industry claims that endgame policies will result in public backlash because they interfere with smokers’ rights.”This study provides evidence that Canadian smokers — those who would be most affected by any policy changes — would support further government action to reduce smoking rates,” said Janet Chung-Hall of the ITC Project and lead author of the study. “The federal government’s commitment to an endgame goal is an important step forward for public health. What we need now is to focus on innovative policies to make it easier for smokers in Canada to quit and to prevent youth from starting to smoke.”last_img read more

Review of research evidence suggests increased suicide rates in highaltitude areas

first_imgRelated StoriesChaos in the house and asthma in children – the connectionChronic inflammation removes motivation by reducing dopamine in the brainTargeting antidiuretic hormone vasopressin shows promise for autismWhy would altitude affect suicide rates? Dr. Kious and coauthors suggest the answer might be “chronic hypobaric hypoxia”: low blood oxygen related to low atmospheric pressure. That theory is supported by studies in animals and short-term studies in humans. The authors suggest two pathways by which hypobaric hypoxia might increase the risks of suicide and depression: by altering the metabolism of the neurotransmitter serotonin and/or through its effects on brain bioenergetics.If borne out by future studies, these mechanisms suggest some possible treatments to mitigate the effects of altitude on depression and suicide risk: supplemental 5-hydroxytryptophan (a serotonin precursor) to increase serotonin levels, or creatinine to influence brain bioenergetics. Dr. Kious and colleagues identify several areas in need of further research, including the effects of prolonged exposure to altitude on both serotonin metabolism and brain bioenergetics.​ Reviewed by James Ives, M.Psych. (Editor)Mar 11 2019High-altitude areas-; particularly the US intermountain states-; have increased rates of suicide and depression, suggests a review of research evidence in the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer.The increased suicide rates might be explained by blood oxygen levels due to low atmospheric pressure, according to the article by Brent Michael Kious, MD, PhD, of University of Utah, Salt Lake City, and colleagues. Pending further research, the evidence may point to possible treatments to reduce the effects of low blood oxygen on mood and suicidal thoughts.Altitude Linked to Variations in Suicide Rate – Further Study of Mechanisms NeededThe researchers reviewed and analyzed previous evidence linking higher altitude of residence to increased risk of suicide and depression, and considered possible explanations for these associations. “There are significant regional variations in the rates of major depressive disorder and suicide in the United States, suggesting that sociodemographic and environmental conditions contribute,” Dr. Kious and coauthors write.They analyzed 12 studies, most performed in the United States, including population-based data on the relationship between suicide or depression and altitude. While the studies used varying methods, most reported that higher-altitude areas had increased rates of depression and suicide. In general, the correlation was stronger for suicide than for depression.The highest suicide rates were clustered in the intermountain states: Arizona, Colorado, Idaho, Montana, Nevada, New Mexico, Utah, and Wyoming. (Alaska and Virginia also had high suicide rates.) In a 2014 study, the percentage of adults with “serious thoughts of suicide” ranged from 3.3 percent in Connecticut (average altitude 490 feet) to 4.9 percent in Utah (average altitude 6,100 feet).Other key findings from previous research on altitude and suicide included: Populations living at higher altitudes had increased suicide rates despite having decreased rates of death from all causes. Rather than a steady increase, the studies suggested a “threshold effect”: suicide rates increased dramatically at altitudes between about 2,000 and 3,000 feet. Suicide rates were more strongly associated with altitude than with firearm ownership. Other factors linked to suicide rate included increased poverty rate, lower income, and smaller population ratios of white and divorced women. However, the studies could not account for all factors potentially affecting variations in suicide, such as substance abuse rates and cultural differences. While more than 80 percent of US suicides occur in low-altitude areas, that’s because most of the population lives near sea level. Adjusted for population distribution, suicide rates per 100,000 population were 17.7 at high altitude, 11.9 at middle altitude, and 4.8 at low altitude. Studies from some other countries, but not all, also reported increased suicide rates at higher altitudes.center_img Source:http://www.lww.com/last_img read more

USC researchers report breakthrough to prevent osteonecrosis of the jaw

first_img Source:https://www.usc.edu/ Reviewed by Alina Shrourou, B.Sc. (Editor)Apr 11 2019USC researchers and collaborators report a breakthrough to prevent damage to the jaw, a side effect suffered by some people undergoing treatment for cancer or osteoporosis.The newly published research is an important step toward a cure for osteonecrosis of the jaw, which is a rare side effect caused by drugs commonly used to combat bone loss. It causes severe and persistent inflammation leading to loss of bone from the jaw and has no effective prevention or cure. The risk, though small, deters people from taking drugs needed to fight bone cancer or prevent fractures due to loss of bone density.USC scientist Charles McKenna said the successful animal experiment, conducted by researchers at USC and UCLA, raises hope that physicians could adapt the new method to treat the condition in people.”This is a condition that has been excruciatingly painful and difficult to treat for more than a decade,” said McKenna, a professor of chemistry in the USC Dornsife College of Letters, Arts and Sciences and adjunct professor of pharmacology and pharmaceutical sciences in the USC School of Pharmacy. “We think our new approach may provide hope for the future”, he said.The new published findings appear in Bone. The authors are affiliated with the USC Center for Drug Discovery and Development at the Michelson Center for Convergent Bioscience, the UCLA School of Dentistry and a Pasadena-based startup biotech company, BioVinc LLC.For years, physicians have prescribed a class of drugs called bisphosphonates (BPs) for metastatic bone cancer patients and to maintain bone density in osteoporosis patients. BPs include a range of compounds that share a remarkable ability to stick to bone like Velcro.But when used in high doses in the cancer clinic, BP drugs sometimes have a terrible side effect causing necrosis in the jaw. The problem often occurs after a tooth is removed, the gap doesn’t heal and the jaw begins to deteriorate.Although the condition is very rare at the lower BP doses used to combat osteoporosis, many patients are avoiding the drugs altogether for fear of the side effects. The risk is low as the National Osteoporosis Foundation estimates incidence of osteonecrosis of the jaw due to BP used to treat osteoporosis to be between 1 in 10,000 and 1 in 100,000 people annually. Risk has been estimated to be much higher, about 3 percent of patients, at the BP dose used to treat cancer, McKennna said.Related StoriesTrump administration cracks down on fetal tissue researchOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchBridging the Gaps to Advance Research in the Cannabis IndustryNonetheless, more and more osteoporosis patients are willing to take their chances with the disease rather than risk the side effects. Surveys have shown the recent trend in reduced hip fractures among post-menopausal women may be reversing due to BP drug aversion.”The fear factor of this condition has led to severe underuse of bisphosphonates for osteoporosis so much so that we’re seeing a rise in hip fractures in elderly people, aversion to bisphosphonates in oncology clinics and liability concerns in the dental office,” McKenna said.To solve the problem, McKennna devised an elegant solution. The research team used a different BP compound, an inactive compound that could be used locally in the mouth to push the BP drug from the jawbone while leaving undisturbed the useful drug in the rest of the skeleton.Said McKenna: “Think of it as a way to fight fire with fire.”The scientists involved in the study used mice to test different BPs attached to fluorescent dyes. One color label coded the BP zoledronate, which is administered systemically to treat osteoporosis and cancer, while a different color labeled “rescue BP” coded a BP compound with similar bone affinity, but no biological activity. The researchers discovered that rescue BP injected into the jaw removed most of the BP drug causing the jaw bone tissue damage, clearing the way for the animal’s natural healing process to repair the extraction site.The new technique isn’t ready for clinical use in humans yet. McKenna said BioVinc, which provided funding for the study via a National Institutes of Health small business research grant, will be responsible for advancing the treatment to commercial clinical use. Several of the authors of the study disclose a financial interest in BioVinc, a company specializing in “bone targeted therapeutics and diagnostics.” McKenna is the company’s academic founder.last_img read more

Study HIV patients continue treatments if health care providers are compassionate

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 15 2019Adults with HIV are more likely to continue life-saving treatments if their primary health care providers show respect, unconditional empathy without judgement and demonstrate an ability to partner with patients in decision making to address their goals, a Rutgers study finds.The systematic review appears in the Joanna Briggs Institute Database of Systematic Reviews and Implementation Reports.The findings showed that the complexity of the illness, treatment regimen and overall healthcare system frequently overwhelms the patient and fear of stigma often prevents them from beginning or continuing treatment. The researchers found that patients need help in understanding their illness and care needs using understandable language to translate complex information, letting patients know what to expect and reinforcing that HIV is now a treatable, yet complex, chronic illness.”Today, HIV is considered a chronic, treatable condition. However, this study found that many patients continue to view it as a death sentence,” said lead author Andrea Norberg, executive director of the François-Xavier Bagnoud Center at Rutgers School of Nursing, which provides care for people with HIV, infectious diseases and immunologic disorders. “We know that people who are knowledgeable about HIV, who are engaged in care and taking antiretroviral therapy medications remain relatively healthy. Our challenge is to reach those people diagnosed with HIV and who are not retained or engaged in ongoing care. In the United States, this is approximately 49 percent of the 1.1 million people diagnosed.”The researchers included 41 studies published between 1997 to 2017. The sample populations included adults with HIV and their healthcare providers. All adults with HIV were between the ages of 18 and 65, represented diverse races and ethnicities, sexual orientations and gender identities. Healthcare providers included physicians, nurse practitioners, physician assistants, pharmacists, social workers and others. The included studies had 1,597 participants.Related StoriesAlcohol reduction associated with improved viral suppression in women living with HIVEven when HIV prevention drug is covered, other costs block treatmentMice cured of HIV in an experiment sparks new hopeThey found that many patients experience stigma and a lack of compassion that is often grounded in primary care providers’ ignorance about HIV and transmission risks. The resulting poor communication between providers and patients results in many patients’ failure to seek or remain in care and adhere to antiretroviral therapy medications.Patients reported feeling “grilled” by providers who often assumed they were not taking medications. Norberg suggested providers would be more successful in getting information from patients by allowing them to be honest, inquiring about their health goals and telling them how other patients have managed treatment.Conversely, the researchers found that patients were more inclined to adhere to HIV treatment when their primary care providers showed empathy, true listening, trust, consideration of the whole person and involvement in decision making. However, many patients reported that healthcare providers viewed care only as “prescribing antiretroviral therapy medicine.””Providers should use common language, not medical jargon, to educate patients about HIV, medications and how they can live a healthy life,” Norberg said. “They should thoroughly teach them about the disease, the medications and side effects, and the meaning of the tests.”The researchers noted that providers who help patients navigate the health system, offer one-stop location of services and provide connections to psychological support, health insurance, medicine, transportation and other services, can help their patients stay engaged in care.Primary healthcare providers can enroll in professional education to improve their knowledge about HIV, use of motivational interviewing skills and seek opportunities for experiential learning, observation and hands-on practice working directly with patients with HIV, Norberg said. Source:Rutgers UniversityJournal reference:Norberg, A. et al. (2019) Experiences of HIV-infected adults and healthcare providers with healthcare delivery practices that influence engagement in US primary healthcare settings: a qualitative systematic review. Joanna Briggs Institute Database of Systematic Reviews. doi.org/10.11124/JBISRIR-2017-003756last_img read more

Interdisciplinary workgroup outlines what is known and unknown about paradoxical lucidity

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 29 2019It happens unexpectedly: a person long thought lost to the ravages of dementia, unable to recall the events of their lives or even recognize those closest to them, will suddenly wake up and exhibit surprisingly normal behavior, only to pass away shortly thereafter. This phenomenon, which experts refer to as terminal or paradoxical lucidity, has been reported since antiquity, yet there have been very few scientific studies of it. That may be about to change.In an article published in the August issue of Alzheimer’s & Dementia , an interdisciplinary workgroup convened by the National Institutes of Health’s (NIH) National Institute on Aging and led by Michigan Medicine’s George A. Mashour, M.D., Ph.D., outlines what is known and unknown about paradoxical lucidity, considers its potential mechanisms, and details how a thorough scientific analysis could help shed light on the pathophysiology of dementia. We’ve assumed that advanced dementia is an irreversible neurodegenerative process with irreversible functional limitations. But if the brain is able to access some sort of functional network configuration during paradoxical lucidity, even in severe dementia, this suggests a reversible component of the disease.”George A. Mashour, professor in the department of anesthesiology, faculty in the neuroscience graduate program, and director of the Center for Consciousness Science The paper describes earlier work documenting case studies of individuals with advanced dementia, including Alzheimer’s disease, appearing to be able to communicate and recall in a seemingly normal fashion at the end of life, to the astonishment of their caregivers.”The accumulation of anecdotal reports about paradoxical lucidity in the scientific literature prompts several important research questions,” says NIA medical officer Basil Eldadah, M.D., Ph.D. “We look forward to additional research in this area, such as better characterization of lucidity in its varying presentations, new instruments or methods to assess episodes of lucidity retrospectively or in real-time, tools to analyze speech patterns or other behavioral manifestations of lucidity, and evidence to inform decision-making challenges and opportunities prompted by unexpected lucidity.”Related StoriesNew app created to help people reduce exposure to anticholinergic medicationsMetformin use linked to lower risk of dementia in African Americans with type 2 diabetesOU Health Sciences Center awarded federal grant to enhance dementia care across OklahomaOne precedent for investigating such events exists in the study of so-called near-death experiences. In 2013, Mashour and his collaborators at Michigan Medicine published a basic science study showing evidence of electrical brain features indicative of a conscious state following cardiac arrest. “We don’t know that the same thing is occurring with paradoxical lucidity, but the fact that this is usually happening around the time of death suggests there could be some common neural network mechanism,” he says.Mashour admits that studying paradoxical lucidity will be a challenge, given the fleeting nature of the event. Case studies report episodes lasting from mere seconds to at most several days for a small minority of cases. The workgroup also outlines important ethical implications of this work, including the ability of vulnerable patients to participate in research and how the observation of paradoxical lucidity might change the way caregivers interact with people with dementia.”Would research that might identify a systematically observable paradoxical lucidity provide comfort, for example, by offering loved ones a potential channel for closure, or might it induce worry if loved ones are left to wonder if a reversible cause of the dementia could have been found? We do not know the answers but these could be important research questions in their own right,” says co-first author Lori Frank, Ph.D., of the RAND Corporation and former Health and Aging Congressional fellow with the National Institute on Aging.The workgroup hopes their paper will help raise awareness within the scientific community to advance paradoxical lucidity research, and help validate the experiences of a multitude of caregivers.Says Mashour, “Science is now trying to be thoughtful and attentive to something that has long been reported.” Source:Michigan Medicine – University of MichiganJournal reference:Mashour, G.A. et al. (2019) Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias. Alzheimer’s & Dementia. doi.org/10.1016/j.jalz.2019.04.002.last_img read more