Beat writer Mark Medina outlines 14 confusing playoff possibilities the Warriors could face and the rotating rest strategy Steve … Click here if you’re having trouble viewing this video on a mobile device.The Golden State Warriors will not know who their opponent in the first round of the playoffs will be until the regular season finale Wednesday.The team concluded its final regular season game at Oracle Arena in Oakland with a 131-104 win against Los Angeles Clippers on Sunday.
Here’s a biological puzzle with plenty of room for young researchers to solve: the workings of biological rhythms. All animals respond to rhythms in periods of hours, days, weeks, months, and years, but as George E. Bentley (UC Berkeley) wrote in Current Biology,1 how they do it is only partially understood. “Sometimes the questions are simple and the answers are complicated,” he ended his article. And complicated it is. Here’s just a portion of the caption to one of his diagrams called “Proposed novel pathways of photoperiodic timing in birds and mammals” to glaze your eyeballs:(A) A diagrammatic representation of the proposed novel pathway for photoperiodic timing in birds. (1) The light signal enters the brain via the skull and is detected by extra-retinal, deep brain photoreceptors (2), the exact identity and location of which are not yet known. Long day lengths induce TSH and Dio2 expression (3) in the pars tuberalis (red) and mediobasal hypothalamus, respectively, thereby causing a local increase in T3. This increase in T3 is conveyed via an unknown pathway to promote the release of gonadotropin-releasing hormone (GnRH) from neurons (4) in the pre-optic area. GnRH then induces the release of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland into the bloodstream to cause gonadal activation (5). Note the lack of involvement of melatonin in this proposed pathway, even though the pineal gland in birds is light-sensitive in its own right. (There will be no quiz.) That was just the bird part. A different complex system exists in mammals. But the complexity does not end there. Animals, with their widely differing gestation periods, exhibit many variations on the theme. Some respond to melatonin and thyroid hormones in different ways, at different rates, and from different parts of the brain. There appears to be no unifying mechanism. From hamster to elephant, animals have not told evolutionists what rules or natural law govern their rhythms (see footnote 3 for two attempts). Bentley commented, “However exciting and potentially important these recent findings might be from the perspectives of ecology, physiology and evolution, it’s obvious that they do not provide us with the full picture. For example, how is this common mechanism tweaked so as to cause short-day breeding in some species and long-day breeding in others?” He did not explain who or what does the tweaking. Bentley’s article was one of several in a special issue of Current Biology devoted to the phenomenon of animal and plant rhythms. In an Editorial in the same issue,2 Albert Goldbeter (U of Brussels) began, “The development and harmonious functioning of an organism depend on the exquisite coordination of myriad intertwined biological processes.” Just one of those is biological timing. Animals need to know when to eat, when to sleep, when to hibernate, when to reproduce, and much more. “The period of biological rhythms spans more than ten orders of magnitude, from a fraction of a second up to tens of years,” he added. These rhythms are tightly coupled to regulatory processes in the cell and the animal as a whole. Only now are scientists beginning to understand the multiple feedback loops and regulatory processes that begin at the molecular level and extend up to the visible behavior of a whole population. This is a field ripe for systems biology – a new approach to biology that keeps the big picture in mind. Goldbeter explained: “Because rhythmic behavior cannot be ascribed to a single gene or enzyme, and rather constitutes a systemic property originating from regulatory interactions between coupled elements in a metabolic or genetic network, cellular rhythms represent a prototypic field of research in systems biology.” For instance, the big-picture look has revealed a phenomenon called the limit cycle. This concept is a central figure in the study of biological rhythms, he said. How do limit cycles work? Models help unraveling the dynamics of cellular rhythms and show that sustained oscillatory behavior often corresponds, in the concentration space, to the evolution toward a closed curve known as a limit cycle. Cycling once around this trajectory takes exactly one period. The closed trajectory is generally unique in a given set of conditions, and is particularly stable as it can be reached regardless of initial conditions.His use of evolution here (one of only two mentions in the two papers) does not refer to Darwinian evolution, but to the unfolding of the limit cycle as a consequence of multiple inputs. The only other mention of evolution, by Bentley, was only a passing reference – and that in the most general terms (see quote in paragraph 2, above). Other papers in the series mentioned evolution only in passing; only two tried to discuss it in some detail, with questionable success.3 In his final paragraph, Goldbeter described the pervasive and intertwined nature of biological rhythms with an analogy. Again, don’t cram for a quiz.The ubiquity and physiological significance of biological rhythms can be illustrated by one last example, which shows how rhythms are often nested in a manner reminiscent of Russian dolls. In the process of reproduction, several rhythms play key roles at different stages and with markedly distinct periods. Fertilization of an egg triggers a train of Ca2+ [doubly ionized calcium] spikes that are essential for successful initiation of development. Prior to these Ca2+ oscillations of a period of the order of minutes, ovulation requires appropriate levels of LH and FSH established through pulsatile signaling by GnRH with a period close to one hour (the response of pituitary cells to GnRH also involves high-frequency Ca2+ oscillations). The ovulation cycle is itself periodic, and takes the form of the menstrual cycle in the human female. Capping these various periodicities, in many animal species reproductive activity varies according to an annual rhythm controlled by the photoperiod, through modulation of the circadian secretion of melatonin. In a final manifestation of the ticking of the biological clock, ovulation stops at menopause. At the very core of life, the reproductive process highlights the deeply rooted links between rhythms and time in biological systems.1. George E. Bentley, “Biological Timing: Sheep, Dr. Seuss, and Mechanistic Ancestry,” Current Biology, Volume 18, Issue 17, 9 September 2008, Pages R736-R738.2. Guest editorial by Albert Goldbeter, “Biological rhythms: Clocks for all times,” Current Biology, Vol 18, R751-R753, 09 September 2008.3. A quick word search on “evolution” in the other six papers in the series found only two discussing it in some detail. One European team’s analysis, however, did not explain how these complex systems actually originated by mutation and natural selection. They provided only a just-so story on how the different mechanisms in different groups of animals might have been related ancestrally. Their language glossed over the origin of a multitude of complex systems with phrases like “the evolution of” and “the development of” sprinkled with doubt-words like probably, likely, may have and our interpretation. They also spoke of the “flow of information” and repeatedly mentioned function without explaining those design-theoretic concepts in Darwinian terms. Overall, it was clear they were assuming evolution rather than demonstrating it; they assumed that natural selection was capable of providing whatever structure that the “evolutionary pressures” were demanding. Here is their complete citation (reiterated with diagram in their Figure 4); it can be considered representative of the other 5 papers in the series that mentioned evolution (most of them with just a passing reference that was not germane to their subject matter, and some with contrary evidence and damaging admissions). The unusual direction of information flow described here probably reflects an ancestral mechanism preceding the evolution of a separation between the hypothalamus and pituitary and the development of a local portal blood system linking the tissues. In ancestral vertebrates (Figure 4, left), it is likely that photoreceptor expression in multiple sites in the central nervous system (CNS) served discrete principal functions: control of vision (lateral eyes), circadian rhythms (pineal structures), and photoperiodism (deep brain and pituitary). In mammals (Figure 4, right), photoreceptor loss has led to the lateral eyes’ assuming all light-sensing functions, with pineal melatonin secretion becoming a humoral relay for photoperiodic information to pituitary and deep-brain sites. Additionally, distinct regions of the ancestral brain have become specialized for different functions, notably the hypothalamus for integration of environmental cues and the pituitary for hormone production. Our interpretation is that photoperiodic control has been assumed by TSH expression at the PT-brain interface, allowing information encoded in the melatonin signal to reach hypothalamic sites. Birds may be viewed as an intermediate scenario in which compartmentalization of endocrine control into sites of integration (hypothalamus) and output (pituitary) has occurred, but extraretinal photoreceptor sites persist. The highly derived state of the photoperiod-transduction pathway in mammals may well reveal the constraints imposed by their nocturnal ancestry.Hanon et al, “Ancestral TSH Mechanism Signals Summer in a Photoperiodic Mammal,” Current Biology, Volume 18, Issue 15, 5 August 2008, Pages 1147-1152.The other paper that discussed evolution in detail arguably only spun just-so stories uneasily in the face of contrary evidence:A re-evaluation of the role of the TTFL [transcriptional/translational feedback loops] in eukaryotes is underway. Can the cyanobacterial clock system [a complex clock in the simplest of unicellular organisms] tell us anything about clocks in eukaryotes? Eukaryotic circadian genes have no detectable homology to kaiABC sequences, so if there is an evolutionary relationship between the bacterial and eukaryotic systems, it is so diverged as to be genetically invisible. But what about the possibility of convergence to a fundamentally similar biochemical mechanism? It might seem implausible that clocks of independent origin would converge upon an essentially similar core PTO [post-translational oscillator] made more robust by an overlying TTFL. However, the advantages that accrue to the cyanobacterial system by having a post-translational mechanism at its core are also relevant to eukaryotic clocks. For example, individual mammalian fibroblasts express cell-autonomous, self-sustained circadian oscillations of gene expression that are largely unperturbed by cell division in a fashion reminiscent of cyanobacteria. Could the necessity for imperturbability, even when buffeted by the massive intracellular changes provoked by cell division, provide an evolutionary driving force for circadian clock mechanisms to converge on a relatively similar core mechanism? The results from cyanobacteria, combined with recent results from eukaryotic systems that do not easily fit into the original TTFL formulation, embolden such speculations.Foster and Roenneberg, “Human Responses to the Geophysical Daily, Annual and Lunar Cycles,” Current Biology, Vol 18, R816-R825, 09 September 2008.Clocks within clocks within clocks – wouldn’t William Paley be astonished. Pay no mind to those Darwinian storytellers in the footnotes; they are assuming 99% of what they need to prove, and still scrambling to come up with plots that thinking people would not laugh at.(Visited 11 times, 1 visits today)FacebookTwitterPinterestSave分享0
CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA Typhoon Kammuri accelerates, gains strength en route to PH “I just got fined,” Kidd said Tuesday night. “That’s one way. The other way is by expressing to the officials and I did that the whole night. The different crews that we’ve had have been awful.”FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout Wall, Beal star as Wizards beat Lakers; Ball’s shooting woes continue Japan ex-PM Nakasone who boosted ties with US dies at 101 View comments Head coach Jason Kidd of the Milwaukee Bucks looks on from the bench while playing the Cleveland Cavaliers at Quicken Loans Arena on November 7, 2017 in Cleveland, Ohio. Cleveland won the game 124-119. Gregory Shamus/Getty Images/AFPNEW YORK — Milwaukee Bucks coach Jason Kidd was fined $15,000 by the NBA on Thursday for public criticism of the officiating in a loss at Cleveland.Kidd made the comments after the 124-119 loss Tuesday night. Milwaukee was called for 31 personal fouls to 18 for Cleveland, and the Cavs attempted 38 free throws. Kidd pointed out that over the past three games, opponents have tried 95 free throws to 40 for Milwaukee.ADVERTISEMENT Don’t miss out on the latest news and information. QC cops nab robbery gang leader, cohort Giannis Antetokounmpo powers Bucks in bounce back win over Celtics PLAY LIST 02:29Giannis Antetokounmpo powers Bucks in bounce back win over Celtics00:50Trending Articles01:48NBA: Kawhi, George seek more for Clippers than beating Lakers01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Read Next Brace for potentially devastating typhoon approaching PH – NDRRMC LATEST STORIES Kammuri turning to super typhoon less likely but possible — Pagasa MOST READ Stronger peso trims PH debt value to P7.9 trillion John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding
Los Angeles Clippers coach Doc Rivers, left, reacts to a call during the second half of the team’s NBA basketball game against the Utah Jazz on Wednesday, April 10, 2019, in Los Angeles. The Clippers won 143-137 in overtime. (AP Photo/Mark J. Terrill)LOS ANGELES — The Clippers won 48 games and made the playoffs without any current or former All-Stars on the roster.Their reward? Getting the defending champion Golden State Warriors in the first round.ADVERTISEMENT “We got a battle ahead of us and it’s about locking in,” said Montrezl Harrell, who scored 24 points to lead seven players in double figures in a 143-137 overtime win over the Utah Jazz on Wednesday night. “We can’t be in awe.”The Clippers snapped a three-game skid to end the regular season, although the losses had already dropped them from the sixth seed to No. 8.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logistics“It’s a whole new season,” Clippers coach Doc Rivers said. “Time to get going.”Ivica Zubac added 22 points and 11 rebounds and Patrick Beverley had 14 points in his return from injury. View comments MOST READ Read Next LAWLER’S NIGHTRalph Lawler called his 3,229th and last regular season game for the Clippers.They even obliged his trademark Lawler’s Law, which states the first team to 100 points wins.Lawler, who turns 81 on April 21, plans to end his 60-year broadcasting career whenever the Clippers are eliminated from the playoffs. He’s handled their games for 40 years.UP NEXTJazz: Meet Houston in first round of Western Conference playoffs.Clippers: Meet defending champion Golden State in first round.Sports Related Videospowered by AdSparc Hontiveros presses for security audit of national power grid Don’t miss out on the latest news and information. Panelo: Duterte ‘angry’ with SEA Games hosting hassles LATEST STORIES SEA Games hosting troubles anger Duterte DA eyes importing ‘galunggong’ anew “It feels good to get out there and play, and have some success scoring and to feel good about my game and how I’m playing,” Allen said. “It’s something I can look back on a little bit later and see how I improved from the beginning of the year.”The Jazz earned the fifth seed and they’ll play No. 4 Houston in the first round.“When you get an opportunity to play postseason basketball you’re excited, but we’re even more excited because they knocked us out of the playoffs last year,” said Georges Niang, who added 24 points.The Clippers dominated overtime, 17-8. Zubac had back-to-back dunks and rookie Jerome Robinson scored six of his seven points.The Jazz outscored the Clippers 29-24 in the fourth after Los Angeles led by nine. Allen had 14 points in the quarter.His free throws put Utah ahead 126-124, but the Jazz fouled Sindarius Thornwell, who made both to tie it up and force overtime.The Clippers shot 71 percent in the first quarter when they led by 17.TIP-INSJazz: F-C Derrick Favors (back spasms) missed his fifth straight game. … C Rudy Gobert (left ankle soreness), G Kyle Korver (right knee soreness), G Donovan Mitchell (thoracic spasm), G Ricky Rubio (left quad contusion) and G Raul Neto (left ankle soreness) sat out. … They have won eight of 10. … They lost the second game of their final back-to-back.Clippers: Beverley returned after missing the last three games with a right hip pointer. … They lost the season series 2-1. PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Philippine Arena Interchange inaugurated Cayetano: Senate, Drilon to be blamed for SEA Games mess Private companies step in to help SEA Games hosting Nuggets slip past Timberwolves to secure West’s no. 2 spot Ethel Booba twits Mocha over 2 toilets in one cubicle at SEA Games venue The Warriors won the season series 3-1, with the Clippers’ lone victory coming in overtime at home on Nov. 12 with some players who are no longer on the team.“The pressure is on them, of course,” Beverley said of Golden State. “Understanding we have to do everything the right way to beat this team.”Rivers joked, “If we could take (Stephen) Curry, (Kevin) Durant and (Klay) Thompson away that would be terrific.”Against the Jazz, the Clippers had seven players in double figures.Grayson Allen led Utah with a career-high 40 points. The rookie made 13 of 14 free throws and five 3-pointers, but was limited to four points in overtime.ADVERTISEMENT
LAVAL, Que. – Valeant Pharmaceuticals International Inc. says a U.S. District Court judge gave his preliminary approval Tuesday to a US$290-million settlement of lawsuits stemming from the unsuccessful attempted hostile takeover in 2014 of Botox maker Allergan Inc.As part of the deal agreed to in December, Quebec-based Valeant (TSX:VRX) will pay US$96.25 million, with co-defendant Pershing Square Capital Management, L.P. paying the rest.Valeant spokeswoman Lainie Keller says approval is subject to submission of final papers and associated hearings.She says that the company continues to believe the resolution of the litigation is in the best interests of the company, enabling it to focus its attention and resources on the transformation of Valeant.Both companies have said they are admitting no wrongdoing by settling. The lawsuit accusing them of insider trading was brought by shareholders who sold Allergan stock in the two months before the US$51-billion bid was launched.Pershing Square CEO Bill Ackman has said he believes the lawsuit was without merit but settling will save resources required for a lengthy litigation.
The Reggae Boyz are facing a possible elimination from the Caribbean Cup as they managed a 0-0 draw against Martinique Monday night at the Sir Vivian Richards Cricket Stadium in St. John’s, Antigua.Jamaica is the defending Caribbean Cup champions, who is attempting to get to the 2013 CONCACAF Gold Cup, but with Monday’s draw they have landed their way at the bottom of Group B. Martinique leads the group with four points, French Guiana and Guiana both have three points, while Jamaica only has one point.Martinique appeared to be the more aggressive and organized team in Monday’s night match. Jamaica appeared to be flustered at times in the first half.Martinique managed to score in the 14th minute of play when Jordi Delem delivered a floated ball in, but the goal was nullified when the referee ruled Martinique offside, according to Sean Williams of the Jamaica Observer.Boyz goalkeeper Dwayne Miller was tested two minutes later when Martinique captain Kevin Parsemain attempted a shot from 25 yards, but Miller denied his strike.Demar Phillips attempted to answer the shots put forth by Martinique in the first half with one of his own. Phillips challenged Martinique goalkeeper Kevin Olimpa with a 30-yard shot, but was unsuccessful as Olimpa denied him.Both teams entered the half scoreless, but the Boyz came out in the second half with a new sense of urgency. They played in a more cohesive manner compared to the first half, but were still unable to penetrate through the Martinique defense.As the Jamaicans were gaining momentum they took a hit in the 62nd minute when left-back Demar Phillips picked up his second yellow card and was sent off the field.Martinique looked to capitalize with the short-handed Boyz in the 86th minute, when Sebastein Cretinoir aimed a 30-yard shot at substitute goalie Duwayne Kerr. Kerr managed to deny Cretinoir’s shot.The Boyz had a final attempt to steal the game when Darren Mattocks split two defenders, but was unable to get a high percentage shot off from inside the box.Jamaica now needs to win against Cuba Tuesday and hope Martinique defeats French Guiana, so they can squeak their way into the knockout phase. They could also hope that the two teams draw in their match, but Martinique winning would be a more favorable outcome for the Reggae Boyz.If none of those scenarios work out in the favor then they will be eliminated and sent back across the water to regroup for the Caribbean Cup next year.
Sophomore goalie Christian Frey skates near his goal during a game against Minnesota at the Schottenstein Center on March 6. OSU lost, 4-2. Credit: Alexis Soares / Lantern photographerIn the final home game of their collegiate careers, OSU’s eight seniors were the stars on the ice one last time.The senior class helped lead the team to a 5-2 victory over the No. 15 Golden Gophers on Saturday.“Led by our seniors, no question,” coach Steve Rohlik said. “We talked a lot about it today and in video session, you can’t script a book any better than what happened tonight, but again, you’re led by eight pretty quality young men. But I credit the team because it takes all 27 guys to get it done, and all 27 guys jumped on board and everybody wanted to do it for the seniors, but more importantly for the program.”Sophomore forward Nick Schilkey’s backhander off a rebound from senior forward Darik Angeli put the Buckeyes in a 1-0 lead.The Gophers notched two tallies in the second period, but senior forward Matt Johnson tied the score at 2-2. OSU then added three goals in the third to take the win.This weekend proved to be a big one for junior defenseman Craig Dalrymple as he scored his first two goals of the season in back-to-back nights against the Gophers.“Two goals in two games, it’s pretty special,” Dalrymple said.OSU’s defense held the game for the Buckeyes by not allowing one of the best power-play units in college hockey to score on its four power-play chances.“That’s a scary team on the power play when you’re clicking at the right percent. They have so many weapons,” Rohlik said. “I think our guys decided it just doesn’t matter, you have to go out and kill a penalty and our guys just jumped the boards and got the job done.”After Minnesota coach Don Lucia decided to pull his goalie late in the final period Saturday to allow the Gophers to add an extra attacker, the Buckeyes took advantage.Led by the stick skills of senior forward Tanner Fritz, the Buckeyes scored twice on an empty net. Fritz assisted junior forward Anthony Greco on the first, and scored the second himself, marking his last home goal as a Buckeye.“I think the hockey gods were shining down on me a little, but definitely nice to go out that way,” Fritz said.Fritz, who leads the Buckeyes with 26 points and has had a point in each of his last six games, said this win was one to remember.“It’s an awesome feeling, something that I’ll remember and cherish down the road. I can look back on this and be proud of what I’ve done,” Fritz said.But the Buckeye captain’s hockey career isn’t over yet, as OSU is set to travel to Madison, Wis., to take on the Wisconsin Badgers in its final series of the regular season.“We enjoy this win. We played a very good hockey team,” Rohlik said. “We are going into their senior weekend and we have to become a better team starting on Monday and that’s our focus. If we can continue to do that, hopefully we can cause some success.”Puck drop in Madison is set for 8 p.m. on Friday and 7 p.m. on Saturday.
Aleksandar Mitrović completed his move from Newcastle to Fulham and he insisted that it was the thing that he wanted to most from the beginning despite the interest being shown from many different clubs.The Serb provided a couple of stellar performances on the World Cup for his national team and he had helped Fulham back to the Premier League before that – so it was clear that Newcastle will have many options where to sell him.The striker spoke about his decision as he said, according to Hammy End:Jose Mourinho is sold on Lampard succeeding at Chelsea Tomás Pavel Ibarra Meda – September 14, 2019 Jose Mourinho wanted to give his two cents on Frank Lampard’s odds as the new Chelsea FC manager, he thinks he will succeed.There really…“I told my agent, my brother, my family that this is the only club I want to join. We didn’t even talk. Especially after the World Cup a few clubs were interested but my heart wanted to come here and to continue where we stopped. I didn’t talk to the other clubs. I know that I want to be here.”“Thanks to Fulham and their fans, the people who work in the club to make this come true. They were really passionate. I thought it might happen sooner [than it did]. It was not easy but in the end, we did it and I’m here. I am happy and proud to officially be a Fulham player.”“When I came here I fitted into the club like I’d been here lots of years. I don’t need time to settle in, I just want to play football and try to make big things with this amazing club.”
Following Barcelona’s 2-0 win against Celta Vigo yesterday, Barca left-back Jordi Alba’s discussed his contract with the club as well as a plan to move for a new deal.Jordi Alba’s contract won’t expire until the summer of 2020, but he confirms he wouldn’t mind moving forward with talks on a new deal.“It doesn’t just depend on me, as it also depends on the club,” he said when asked about a new contract after the game via Marca.“When I signed for Barcelona it wasn’t for money.“I came here for the feeling and because it is my home.“In the end, it’s not enough to say that I’m a great player, as actions also matter.“A deadline? When the contract ends.”Lionel Messi and Jordi Alba played together again in the clash against Celta Vigo and the left-back spoke of the bond with Lionel Messi.Mourinho: “Lionel Messi made me a better coach” Andrew Smyth – September 14, 2019 Jose Mourinho believes the experience of going up against Barcelona superstar Lionel Messi at Real Madrid made him a greater coach.“For the first goal he was looking for me and I held the run well,” he said afterward.“On the second, [Ousmane] Dembele and Luis Suarez’s runs left him alone and he never fails.“I know that most of the assists I give will end up going on [the goal].”“We faced a great team that like to play football,” he added.“The first half was very good and in the second we dropped our rhythm a bit and they were able to create.“We are happy with the result.”Barcelona won’t have any more fixtures until a clash with Getafe on January 6.